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“Non-nodular Type” in Lateral Spreading Tumor, Report of a Case Yasushi Oda 1 , Takahiro Fujii 1 , Ikuro Koba 1 , Hisao Tajiri 1 , Shigeaki Yoshida 1 1National Cancer Center Hospital East Keyword: 表層拡大型大腸腫瘍 , p53 , K-ras pp.235-241
Published Date 1996/2/25
DOI https://doi.org/10.11477/mf.1403103952
  • Abstract
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 A 70-year-old man was admitted to have an operation for early gastric cancer. During the examination of the colon before the operation, a superficial tumor was detected. Barium enema and endoscopic examinations showed a flat elevated tumor, 30 mm in size, at SD junction. The shape of the margin of this tumor was like that of an amoebae with protruding edges. Examination of the resected specimen showed that the macroscopic diagnosis was flat elevated type, 33 mm in diameter with slight sm invasion. From the characteristics of the surface and edge's shape, we have proposed that this type of superficial tumor to “Non-nodular type” lateral spreading tumor. Overexpressions of p53 were detected all over this tumor, K-ras Codon 12 point mutations were not detected and APC LOH yolded no information. “Non-nodular type” was compared with “Nodular type” called Nodular-aggregating tumor in p53 overexertions and K-ras point mutations. Overexpressions of p53 were seen in 61% (11/18 cases) in “Non-nodular type” and 34% (10/29 cases) in Nodular type respectively. In addition, “Non-nodular type” were stained diffusely all over the tumor in spite of histology and Nodular type were stained focally in coincidence with the cancer. K-ras mutations were seen in 0% (0/18 cases) and 60% (24/40 cases) respectively. These characteristics of Non-nodular type were compatible with those of superficial depressed tumor.


Copyright © 1996, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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