Histopathological and Molecular Biological Characterization of Laterally Spreading Tumors Compared with Other Macroscopic Types of Colorectal Tumor Kenichiroh Mukawa 1,2 , Keiichi Tominaga 1,2 , Naoto Yoshitake 1,2 , Hideyuki Hiraishi 2 , Takahiro Fujimori 1 1Department of Surgical and Molecular Pathology, Dokkyo University School of Medicine 2Department of Gastroenterology, Dokkyo University School of Medicine Keyword: LST , laterally spreading tumor , K-ras , p53 , E-cadherin pp.1847-1853
Published Date 2005/12/25
DOI https://doi.org/10.11477/mf.1403100194
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 The “laterally spreading tumor (LST)” have been known as a lesion larger than 10 mm in diameter and extending circumferentially rather than vertically and they are classified into two subtypes : granular (LST-G) and non granular (LST-NG). However, they are not defined definitely at present.

 We analyzed the clinicopathological and molecular biological features of LSTs compared with other macroscopic types of colorectal tumor (protruded type I, superficial elevated type IIa and IIa+IIc, depressed type IIc and IIc+IIa).

 These results suggested that LSTs should be classified as an independent disease entity. In our study, LST-G is similar to protruded type tumor and one part of LST-NG is similar to depressed type tumor, however, the other part of LST-NG is similar to protruded type tumor.

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