Multiple Early Gastric Cancers from the Standpoint of Endoscopic Mucosal Resection and Helicobacter pylori Infection Eiji Umegaki 1 , Nozomi Takeuchi 1 , Masaya Tanaka 1 1The Second Department of Internal Medicine, Osaka Medical College Keyword: Helicobacter pylori , 同時性多発胃癌 , 異時性多発胃癌 , 胃粘膜切除術 pp.1657-1663
Published Date 2001/12/25
DOI https://doi.org/10.11477/mf.1403103390
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 The WHO/IARC designated Helicobacter pylori (H. pylori) as a definite carcinogen (1994), and the Maastricht Consensus Report considers early gastrectomy patients an absolute indication for H. pylori eradication therapy (1996). Our aim in this study was to investigate the association of H. pylori infection with the occurrence of lesions in patients who undergo endoscopic mucosal resection (EMR) for early gastric cancer or gastric adenoma from the standpoint of lesions and background gastric mucosa.

 When the background gastric mucosa was evaluated histopathologically, differentiated gastric cancer tended to have gastric mucosal atrophy accompanied by intestinal metaplasia as a background, while undifferentiated gastric cancer tended to have unatrophied mucosa as a background.

 The mode of lesion development was investigated in patients with gastric adenoma and gastric cancer. Multiple lesions accounted for 18.5% of patients, of whom 89.3% had simultaneous, multiple lesions. As for the infection of H. pylori, there was no difference in incidence of H. pylori infection according to the mode of lesion development.

 When these findings are coupled with the frequent simultaneous development of multiple lesions, post-EMR H. pylori eradication therapy seems to have limitations and further study is required.

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