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Clinical Pathology of Gastrointestinal Stromal Tumor (GIST): With Special Reference to Change of the Cencept of Gastrointestinal Mesenchymal Tumor (GIMT) and the Definition and Organ Specificity of GIST Akinori Iwashita 1 1Department of Pathology, Chikushi Hospital, Fukuoka University Keyword: GIMT , GIST , 概念の変遷 , 定義臓器特異性 pp.1113-1127
Published Date 2001/8/25
DOI https://doi.org/10.11477/mf.1403103294
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 A total of 251 operated cases of gastrointestinal mesenchymal tumor (GIMT) were studied. Special notice was made of 105 cases of stromal tumor (GIST in a narrow sense) which were analyzed from a clinico-pathological standpoint of view. Using Rosai's classification, the cases of GIMT were classified into 137 cases of smooth muscle type, 7 of neural type, 2 of combined smooth muscle-neural type, and 105 of uncommitted type (GIST in a narrow sense). The sites of the 105 lesions of GIST were the esophagus no cases, the stomach 81 cases, the small intestine 16 cases, and the large intestine 8 cases. The rate of GIST among all cases with GIMT was also significantly lower in the esophagus as compared with other sites. Histologically, the tumors were benign in 19 cases, intermediate in 22 cases, and malignant in 64 cases, and the average number of mitoses of those tumors was 2.4, 13.5, and 17.6/HPF, respectively. The rate of malignant tumor for each site of involvement was 54.3% in the stomach, 75% in the small intestine, and 100% in the large intestine, and a significant difference was noticed between the rates stomach and large intestine malignancy. From those results, it was pointed out that GIST was rare in the esophagus and that the rate of malignant tumors was very high in the large intestine. In addition, changes in the concept of GIMT and its definition as well as indices of maligancy and histogenesis of GIST were briefly described.


Copyright © 2001, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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