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Clinicopathological Study of Early Colorectal Carcinoma by Using the Polypectomized Specimens Masato Otsuji 1,2 , Kyoichi Nakamura 1 1Department of Pathology, Faculty of Medicine, University of Tsukuba Keyword: 癌組織発生 , 大腸早期癌 , ポリペクトミー標本 pp.793-801
Published Date 1991/7/25
DOI https://doi.org/10.11477/mf.1403102586
  • Abstract
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 Early colorectal carcinoma was clinicopathologically studied by examining polypectomized specimens.

 Seventy one cases of early colorectal carcinoma chosen for the present study were those in which polypectomized specimens were more than 1 cm in diameter. These cases were classified into two categories using indices of atypical glands to determine histogenesis. Twenty five cases diagnosed as de novo carcinoma and 46 cases were carcinoma in adenoma.

 De novo carcinoma and carcinoma in adnoma did not show any differences in size. Most of the former were, however, macroscopically found to be sessile lesions (Ⅰs, Ⅱa) while most of the latter were pedunculated lesions (Ⅰp).

 In 60% of the cases of carcinoma in adenoma, hyperplastic glands and/or adenoma components could be observed between the cancer glands and the muscularis mucosae. In contrast to the above, cancers were found to touch the muscularis mucosae directly in 90% of the cases of de novo carcinoma. Infiltration into the submucosal layer was observed in 8 cases out of 25 (32%) of de novo carcinoma.

 Therefore, de novo carcinoma seems to be more likely to infiltrate into the submucosal layer than carcinoma in adenoma.

 Histological observation on the stump after polypectomy revealed cancer glands near or on the stumps in 20 cases out of 25 (8O%) of de novo carcinoma, and in 12 cases of 46 (26%) of carcinoma in adenoma.

 These findings suggest that histogenesis of colorectal carcinoma should be indentified for determining appropriate clinical treatment. This precaution will reduce the possibility of recurrence and/or residue of colorectal carcinoma.


Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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