Gastric Syphilis:Morphologic Resemblance between Gastric Lesions and Skin Manifestations in Secondary Syphilis, Report of Two Cases Hiroyuki Kobayashi 1 , Tadahiko Fuchigami 1 , Akinori Iwashita 3 1Institute of Gastroenterology, Matsuyama Red Cross Hospital 3Department of Pathology, Fukuoka University Chikushi Hospital Keyword: 第2期梅毒 , 胃梅毒 , 梅毒性皮疹 , 胃びらん , 抗スピロヘータ酵素抗体法 pp.545-551
Published Date 1991/5/25
DOI https://doi.org/10.11477/mf.1403102538
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 Two cases of secondary syphilis with gastric lesions are presented.Both had irregular-shaped ulcerative lesions in the antrum, which is considered to be characteristic to gastric syphilis.In addition, they had multiple large verruciform lesions in the gastric body.The presence of Treponema pallidum was confirmed by immunohistochemical staining(ABC method)of biopsy specimens taken from these lesions.Treatment with penicillin led to prompt disappearance of both verruciform and antral lesions.

 Based on these observations, we considered that ulcerative lesions in the antrum and verruciform ones in the body were both gastric manifestations of secondary syphilis.

 Interestingly, large verruciform lesions resembled syphilitic skin lesions.Our speculation is that gastric mucosal changes in secondary syphilis develop by the same pathologic mechanism whereby syphilitic skin lesions develop.

Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.


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