Surveillance Study on Cancer and Dysplasia Associated with Ulcerative Colitis Kimitaka Suzuki 1 , Tetsuichiro Muto 1 , Senichiro Agawa 1 , Yoshiro Kubota 1 , Yasuhiko Morioka 1 1The First Department of Surgery, Faculty of Medicine University Keyword: 潰瘍性大腸炎 , 大腸癌 , dysplasia , サーベイランス , 核DNA量 pp.511-520
Published Date 1991/5/25
DOI https://doi.org/10.11477/mf.1403102533
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 Surveillance colonoscopy has been performed to detect dysplasia and surgically treatable carcinoma in patients with ulcerative colitis. A total of 261 surveillance colonoscopies were carried out in 90 patients with longstanding ulcerative colitis of total or left sided type between 1979 and 1990. Out of 63 patients with total colitis, including 19 with rectal stump who had undergone colectomy and ileo-rectal anastomosis, 3 had carcinoma, 2 high-grade dysplasia, 4 low-grade and 9 indefinite for dysplasia. Out of 27 patients with left sided colitis, one had low-grade dysplasia and another one indefinite for dysplasia. The overall incidence of dysplasia including indefinite cases was 22%, similar to the reported incidence from western countries. All these patients who had carcinoma are alive and well postoperatively during 3-year period of follow-up. Microspectrophotometric DNA measurement has proved useful in diagnosing dysplasia associated with ulcerative colitis. Surveillance colonoscopy is useful in selecting patients at high risk of carcinoma at curative stage.

Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.


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