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Cytokines as Therapeutic Targets for Behçet's Disease Mitsuhiro Takeno 1 , Yoshiaki Ishigatsubo 1 1Department of Internal Medicine and Clinical Immunology, Yokohama City University Graduate School of Medicine, Yokohama, Japan Keyword: Behçet病 , Th1 , Th17 , 抗TNF-α抗体 , GWAS pp.1073-1080
Published Date 2011/6/25
DOI https://doi.org/10.11477/mf.1403102280
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 Behçet's disease is a systemic inflammatory disease of unknown cause. In addition to genetic factors such as HLA-B51, environmental factors are also involved in the immunopathogenesis of the disease. Recent genome-wide association studies identified IL10 and IL23R-IL12RB2 as novel susceptible genes for the disease, suggesting that Th1 and Th17 autoimmune responses are implicated in the disease process. Abnormal innate immune responses including neutrophil hyperfunction and aberrant expression of toll-like receptors also contribute to development of the disease.

 Treatment with anti-TNF(tumor necrosis factor)-α antibody is very effective, while the effects depend on blood levels of the agent. In contrast,IFN(interferon)-α shows long-lasting efficacy without relapses, though the pharmacological mechanisms remain unclear. These clinical observations may shed light on the novel aspects of the pathogenesis of Behçet's disease.


Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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