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Etiology and Risk Factors of Superficial Esophageal Cancer Osamu Chino 1 , Soji Ozawa 1 , Hideo Shimada 2 , Soichiro Yamamoto 1 , Minoru Nakui 1 , Akihito Kazuno 1 , Hiroyasu Makuuchi 3 1Department of Surgery, Tokai University School of Medicine, Isehara, Japan 2Department of Surgery, Tokai University Oiso Hospital, Kanagawa, Japan 3Tokai University School of Medicine, Isehara, Japan Keyword: 食道癌 , 疫学 , 危険因子 , 重複癌 pp.553-560
Published Date 2011/5/24
DOI https://doi.org/10.11477/mf.1403102213
  • Abstract
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 Development of esophageal cancer is regarded as being related to the area, the race, dietary habits, smoking and drinking.

 The mortality rate because of esophageal cancer in Japan is keeping its level in men, but decreasing in women. The morbidity is slightly increasing in men, but shows a decreasing tendency in women.

 Esophageal cancer in Japan occurs predominantly amongst males and is most frequently encountered in the 60 to 70 year age group. The most frequent location of the lesion is the middle thoracic esophagus and diagnosed mostly as squamous cell carcinoma.

 It is also well-known to often involve double cancer synchronously or metachronously.

 The risk factors of esophageal squamous cell carcinoma include smoking and alcohol, as well as head and neck cancer, esophageal achalasia, and cottosive esophagitis.

 The risk factors of esophageal adenocarcinoma include Barrett's epithelium caused by chronic continuous inflammation in the lower esophagus caused by gastro esophageal reflux disease.

 Endoscopical screening in these high risk groups is recommended.


Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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