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Molecular Analysis of Gastric Differentiated Intramucosal Cancers Based on Mucin Phenotype Tamotsu Sugai 1 , Wataru Habano 2 , Masaki Endo 3 , Risaburo Akasaka 1,3 , Hitohiko Koizuka 1,3 , Yasuhiro Konishi 1 , Yoshiharu Mue 1 , Keisuke Koeda 4 , Go Wakabayashi 4 , Kazuyuki Suzuki 3 1Division of Molecular Diagnostic Pathology, Department of Pathology, Iwate Medical University, Morioka, Japan 2Department of Pharmacodynamics and Molecular Genetics, School of Pharmacy, Iwate Medical University, Morioka, Japan 3Division of Gastroenterology and Hepatology, Department of Internal Medicine, Iwate Medical University, Morioka, Japan 4Department of Surgery, Iwate Medical University, Morioka, Japan Keyword: 胃癌 , MSI , メチル化 , 粘液形質 , LOH pp.1432-1440
Published Date 2009/8/25
DOI https://doi.org/10.11477/mf.1403101741
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 Background and aims : Identification of molecular characteristics of intramucosal cancers is essential to understand early gastric carcinogenesis. However, little has been known regarding the lesions. Materials and Methods : One hundred and nineteen patients with gastric differentiated-type intramucosal cancers(GDICs)were classified according to tumor mucin phenotype(gastric, intestinal, mixed and unclassified types). p53 overexpression, cell proliferative activity, loss of heterozygosity(LOH), microsatellite instability(MSI)and methylation status using a panel of 20 microsatellite markers(3p, 4p, 5q, 9p. 13q, 17p, 18q and 22q)and promoter regions of 9 genes(MLH-1, RUNX3, p16, HPP1, RASSF2A, SFRP1, DKK-1, ZFP64 and SALL4)were examined in 119 patients with GDICs. Results. p53 overexpression of gastric phenotype cancer was more frequently found compared with that of mixed phenotype cancer. Whereas multiple LOHs of tumor cells occurred in gastric phenotype cancers, they were infrequently detected in intestinal or mixed phenotype cancers. In addition, methylation at cancer-related genes is a common event in GDICs. Conclusions. Our data confirm that distinct molecular alterations in the GDICs are characterized by tumor mucin phenotype.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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