Japanese

Molecular Carcinogenesis of Colorectal Tumor Tamotsu Sugai 1 , Wataru Habano 2 1Division of Molecular Diaguostic Pathology, Department of Pathology, Iwate Medical University, Morioka, Japan 2Department of Pharmacodynamics and Molecular Genetics, School of Pharmacy, Iwate Medical University, Morioka, Japan Keyword: 大腸癌 , 多段階発癌 , LOH , CIMP , 細胞周期 pp.1965-1974
Published Date 2008/12/25
DOI https://doi.org/10.11477/mf.1403101542
  • Abstract
  • Look Inside
  • Reference
  • Cited by

 Colorectal cancer(CRC)is one of the most frequent cancers in the Western world. CRC development is a multi-step process that is associated with multiple molecular alterations. Recent studies have shown that three main pathways occur in CRC, including chromosomal instability(CIN), microsatellite instability(MSI)and epigenetic silencing through the CpG Island Methylator Phenotype(CIMP). These pathways have distinct clinical, pathological, and genetic characteristics, which can be used for molecular classification, prognosis and treatment in CRC. This review aims to give an overview of the evolving molecular concepts in CRC, with concern for their potential for clinical implications for the gastrointestinal clinicians.


Copyright © 2008, Igaku-Shoin Ltd. All rights reserved.

基本情報

電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

関連文献

もっと見る

文献を共有