Molecular Carcinogenesis of Colorectal Tumor Tamotsu Sugai 1 , Wataru Habano 2 1Division of Molecular Diaguostic Pathology, Department of Pathology, Iwate Medical University, Morioka, Japan 2Department of Pharmacodynamics and Molecular Genetics, School of Pharmacy, Iwate Medical University, Morioka, Japan Keyword: 大腸癌 , 多段階発癌 , LOH , CIMP , 細胞周期 pp.1965-1974
Published Date 2008/12/25
DOI https://doi.org/10.11477/mf.1403101542
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 Colorectal cancer(CRC)is one of the most frequent cancers in the Western world. CRC development is a multi-step process that is associated with multiple molecular alterations. Recent studies have shown that three main pathways occur in CRC, including chromosomal instability(CIN), microsatellite instability(MSI)and epigenetic silencing through the CpG Island Methylator Phenotype(CIMP). These pathways have distinct clinical, pathological, and genetic characteristics, which can be used for molecular classification, prognosis and treatment in CRC. This review aims to give an overview of the evolving molecular concepts in CRC, with concern for their potential for clinical implications for the gastrointestinal clinicians.

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