Gastrointestinal Stromal Tumor of the Stomach Arising from the Muscularis Mucosae, Report of a Case Kenji Yamazaki 1 , Yoriko Hanai 1 , Takahiro Kochi 1 , Kentaro Otsuji 1 , Masahiro Mihara 1 , Naoki Katsumura 1 , Norio Okumura 2 , Yoji Kawai 2 , Hiroshi Araki 3 , Hirofumi Shimojo 4 , Yoshio Mori 5 , Kuniyasu Shimokawa 6 1Department of Gastroenterology, Chuno Kousei Hospital, Seki, Japan 2Department of Surgery, Chuno Kousei Hospital, Seki, Japan 3Department of Gastroenterology, Gifu University School of Medicine, Gifu, Japan 4Shimojo clinic, Seki, Japan 5Department of Pathology, Chuno Kousei Hospital, Seki, Japan 6Department of Pathology, Yamauchi Hospital, Gifu, Japan Keyword: , GIST , 粘膜筋板 pp.1037-1044
Published Date 2009/5/25
DOI https://doi.org/10.11477/mf.1403101690
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 On gastrointestinal endoscopy, a 69-year-old female was found to have a pedunculated tumor in the greater curvature of the gastric upper body. Biopsy findings led us to diagnose a gastrointestinal stromal tumor(GIST), and partial resection of the stomach was carried out. The resected tumor was 45×25mm in size, and, on immunohistochemistry, was positive for c-kit but negative for S100 protein and desmin. These findings confirmed the diagnosis of GIST. Of special interest is the fact that the tumor was connected to the muscularis mocosae. In Japan there have been only two previous reports of GIST located in the stomach arising from the muscularis mucosae. Herein we show morphological changes of GIST observed over a period of 19 month.

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