Stomach and Intestine(Tokyo) Volume 44, Issue 2 (February 2009)

Phlebosclerotic Colitis with a Thickened Collagen Layer beneath the Surface Epithelium─Immunohistochemical Study for Collagen, Report of a Case Ayako Nishimura 1 , Naoko Masuzawa 1 , Takeshi Nishimura 2 , Kojiro Nakase 2 , Eisai Cho 2 , Mitsuo Kishimoto 1 1Department of Pathology, Otsu Municipal Hospital, Otsu, Japan 2Department of Gastroenterology, Otsu Municipal Hospital, Otsu, Japan Keyword: 静脈硬化性大腸炎 , collagenous colitis , 膠原線維 , テネイシン , IV型コラーゲン pp.214-220
Published Date 2009/2/25
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 A 68-year-old woman was admitted to our hospital because of right abdominal pain and watery diarrhea. We made a diagnosis of phlebosclerotic colitis in the cecum, the ascending colon and the transverse colon with findings of abdominal computed tomography, colonoscopic examination and biopsy specimens showing perivascular fibrosis. In addition, the biopsy specimens showed a band-like collagen layer just beneath the surface epithelium extending from the ileocecum to the rectum. We immunohistochemically analyzed the collagen tissues abnormally deposited in different ways and ranges. The band-like collagen layer was positive for tenascin and negative for collagen type IV. While the perivascular collagen was negative for tenascin, immunoreactivity of collagen type IV was prominent for the collagen within the blood vessel walls but not present around the blood vessels. We could not determine whether this case should be diagnosed as phlebosclerotic colitis complicated by collagenous colitis or not, as immunoreactivity for collagen deposited in phlebosclerotic colitis had never been examined.

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44巻2号 (2009年2月)
電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院