A Novel Method of Endoscopic Diagnosis of the Colon, Autofluorescence Imaging(AFI) Ryu Sato 1,2,3 , Mikihiro Fujiya 1,2 , Kentaro Moriichi 2 , Toshie Nata 2 , Nobuhiro Ueno 2 , Youkou Konno 2 , Chisato Ishikawa 2 , Takahiro Ito 2 , Kotaro Okamoto 2 , Hiroki Tanabe 2 , Atsuo Maemoto 2 , Jiro Watari 1,2,3 , Toshifumi Ashida 2 , Yusuke Saitoh 4 , Yutaka Kohgo 1,2 1Division of Endoscopy, Asahikawa Medical Collage Hospital, Asahikawa, Japan 2Division of Gastroenterology and Hematology/Oncology, Department of Medicine, Asahikawa Medical College, Asahikawa, Japan 3Kushiro Medical Association Hospital, Kushiro, Japan 4Department of Internal Medicine, Asahikawa City Hospital, Asahikawa, Japan Keyword: AFI , 潰瘍性大腸炎 , 大腸腺腫 , 大腸癌 pp.910-920
Published Date 2008/5/25
DOI https://doi.org/10.11477/mf.1403101382
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 Autofluorescence Imaging (AFI) is a novel procedure to detect autofluorescence emitted from intestinal tissues and apply the alterations of the fluorescence intensity to diagnose intestinal disorders. Disease activity of ulcerative colitis could be assessed with AFI according to our classification (G; green, GP; green with purple spots, PG; purple with green spots, P; purple) and was inversely proportional to fluorescence/reflex ratio calculated with software for measuring the luminous intensity. AFI could predict UC activity as 90%when the cut-off fluorescence/reflex ratio was supposed as 0.9. Whereas AFI easily detected colon neoplasms as a purple area, the intensity of auto-fluorescence emitted from adenomas revealed no difference compared with that from cancers even in the advanced stage, indicating little significance of AFI for diagnosing the grade of dysplasia or the invasion depth of cancer. AFI appears to contribute to the evaluation of UC activity and detection of colon neoplasms.

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