Superficial Esophageal Adeno-endocrine Cell Carcinoma with the Appearance of a Submucosal Tumor Located in the Esophagogastric Junction, Report of a Case Shinichi Katsuki 1 , Tomoki Fujita 1 , Naohito Ohomi 1 , Ken Sawada 2 , Kouichi Okuya 2 , Jun Araya 2 , Eri Ezoe 2 , Kazuaki Sasaki 2 , Yoshito Takada 2 , Masahiro Fujita 3 , Daiki Chiba 4 , Hiroyuki Ohnuma 4 , Rika Ohnishi 4 , Takahiro Kogawa 4 , Eriko Waga 4 , Yasuyuki Yamada 4 , Junki Fukaura 4 , Hiroyoshi Sasaki 4 , Tetsuji Takayama 4 , Junji Kato 4 , Yoshiro Niitsu 4 1Department of The Center of Gastroenterology, Otaruekisaikai Hospital, Otaru, Japan 2Department of Surgery, Otaruekisaikai Hospital, Otaru, Japan 3Keiyuhkai Institute of Clinical Pathology, Sapporo, Japan 4Internal Medicine(4), Sapporo Medical University, Sapporo, Japan Keyword: 食道胃接合部 , 粘膜下腫瘍 , 腺・内分泌細胞癌 pp.1929-1935
Published Date 2007/12/25
DOI https://doi.org/10.11477/mf.1403101248
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 A 64-year-old male was admitted to our hospital with the complaint of epigastric pain and tarry stool due to a duodenal ulcer. Initial endoscopic examination revealed another flat elevated lesion at the esophagogastric junction measuring 25 mm in diameter. The biopsy specimen revealed adenocarcinoma of the esophagus. Resection of the distant esophagus and total gastrectomy was perfomed.

 In the resected specimen, the tumor was located completely in the submucosal layer, and covered with normal squamous and columnar epithelium.

 Immunohistologically, tumor cells were positive for chromogranin A, Grimelius, synaptophysin, and serotonin. The lesion was finally diagnosed as adeno-endocrine cell carcinoma. This patient has had no recurrence and has survived for 29 months since the operation.

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