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要旨●大腸T1癌の内視鏡切除において,腫瘍浸潤先進部から深部断端までの距離(VM)≧500μmの確保は局所再発抑制の観点で重要である.既報の通り筆者らは,EUS上の腫瘍先進部から固有筋層までの距離(tumor-free distance ; TFD)に基づく“EUS-TFD分類”を提唱した.今回,JNET分類Type 2B症例の解析において,EUS-TFD分類Type I群はType II群よりも有意にVM≧500μmの割合が高く(p<0.01),多変量解析において独立した予測因子であった.EUS-TFD分類はESDによるVM≧500μmで完全一括切可能な術前予測因子として有用であり,JNET分類Type 2B症例における内視鏡切除適応の有無を決定するうえで有用な指標と考えられた.
In endoscopic T1 colorectal cancer resection, securing a vertical margin(VM)of ≥500μm(the distance from the deepest tumor front to the deep margin)is considered crucial for suppressing local recurrence. As previously reported, we proposed the “endoscopic ultrasonography-tumor-free distance(EUS-TFD)classification” based on the distance from the tumor invasive front to the muscle layer on EUS(TFD). In the analysis of JNET Type 2B cases, the EUS-TFD Type I group had a significantly higher achievement rate of VM ≥500μm than the Type II group(p<0.01)and was an independent predictor in the multivariate analysis. This classification is useful as a preoperative predictor for achieving complete en bloc resection with VM ≥500μm by ESD and is considered an important determinant of the indication for endoscopic resection in JNET Type 2B cases.

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