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要約 目的:40歳未満の増殖糖尿病網膜症(PDR)に対する25Gおよび27G小切開硝子体手術の術後視力および合併症を調査し,視力予後に影響する因子を検討する。
対象と方法:2015年5月〜2021年6月に順天堂大学医学部附属浦安病院で初回硝子体手術を受けた40歳未満のPDR患者35例50眼(平均年齢:35.1±3.9歳,平均観察期間:30.5±19.5か月,男性21例28眼,女性14例22眼)を対象とし,術後視力および合併症を後ろ向きに調査した。
結果:術後最終視力(logMAR値)は0.42±0.35で,小数視力は0.1未満が10%,0.5以上が68%,0.7以上が58%であった。68%の症例で術前と比較してlogMAR値が0.2改善し,14%が悪化した。術後合併症として,36%の症例で硝子体出血,14%で再増殖,6%で血管新生緑内障(NVG)を認め,術後再増殖が視力悪化に有意に影響した。
結論:若年PDRに対する硝子体手術は,術後視力の改善とNVG発症率の低下を認めた。しかし,再増殖は依然として重要な予後不良因子であり,注意を要する。
Abstract Purpose:To investigate the postoperative visual acuity and complications related to 25 gauge and 27 gauge micro-incision vitrectomy surgery(MIVS)in patients aged below 40 years old with proliferative diabetic retinopathy(PDR), and to identify factors that affect visual prognosis.
Subjects and methods:This study included 35 cases(50 eyes)of PDR patients under 40 years old who underwent initial vitrectomy at Juntendo University Urayasu Hospital from May 2015 to June 2021. Their mean age was 35.1±3.9 years, with a mean follow-up period of 30.5±19.5 months. There were 21 males(28 eyes)and 14 females(22 eyes). Postoperative visual acuity and complications were retrospectively analyzed.
Results:The final postoperative visual acuity was 0.42±0.35 logMAR. The proportion of cases with visual acuity less than 0.1 was 10%, those with 0.5 or better was 68%, and those with 0.7 or better was 58%. Compared to preoperative visual acuity, 68% of cases showed an improvement of 0.2 logMAR after surgery but 14% showed deterioration. Postoperative complications included vitreous hemorrhage in 36% of cases, reproliferation in 14%, and neovascular glaucoma(NVG)in 6%. Postoperative reproliferation significantly affected visual deterioration.
Conclusion:Vitrectomy for young PDR patients improved postoperative visual acuity and reduced incidence of NVG. However, reproliferation remained a significant adverse prognostic factor.
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