インターフェロン—α投与にて縮小した転移性脊椎腫瘍（腎癌）の1例

A Case of Metastatic Spinal Tumor from Renal Cancer Reduced by Interferon-α

I．はじめに

　腎癌の脊椎転移例は予後不良と言われている．またインターフェロン—α^8,9）投与にて肺転移，上腕骨転移巣が縮小したとの報告はあるが，脊椎転移巣が縮小したため全摘出来た報告はない．今回われわれは脊椎転移巣が1カ所で，且つインターフェロン—α投与にて転移巣の縮小を認めたため全摘出でき，脊髄症状の改善が得られた症例を経験したので報告する．

A case of metastatic spinal tumor from renal cancer re-duced by interferon- α is reported. A 54-year-old man was admitted to Tane General Hospital on April 12, 1990, with the complaint of difficulty in walking. Abdo-minal CT scan revealed right renal carcinoma, and MRI demonstrated metastatic spinal tumor at Th6, which was mainly occupying the entire lamina, spinous process and right pedicle of Th6. Nephrectomy was performed and, instead of operating on the spinal lesion, the patient was given follow-up treatment with administration of interferon-α (5 million units twice a week) and steroid. 1 year and 6 months later the patient's walking ability be-gan to deteriorate and paraparesis progressed, although the size of the metastatic spinal tumor had gradually re-duced. This was thought to be because of atrophy of the legs due to prolonged bed rest and steroid administra-tion. Laminectomy with total removal of the tumor was performed on January 16, 1992. In the 12 months post-operatively, there has been neither recurrence nor re-mote metastasis seemingly due to the administration of interferon- α . This appears to be the first report of metastatic spinal tumor from renal cancer reduced by interferon-α.