実験的梗塞脳における病理組織学的研究

HISTOPATHOLOGICAL STUDY ON EXPERINIMENTAL CEREBRAL INFARCTION IN RAT

I．はじめに

　脳組織は，酸素に対する予備力が低く，酸素供給に関しては，時々刻々の血流に依存している。したがつて，脳血管の一部に血流の障害が起こり，かつその部の側副血行が不十分な場合には，比較的早期にその灌流域の組織は，局所性虚血に陥るため，その部の変性壊死をきたし，脳の機能の脱落をきたす。今回，われわれは，この脳血管障害によつて起こる脳の器質および機能障害の機序の解明を目的にラットを用いて実験的脳梗塞のモデルを作成し，主として病理組織学的な検討を加えたので報告する。

An experimental model of cerebral infarction in rat brain was successfully established by means of the unilateral internal carotid injection of carbon microspheres. A histopathological investigation of the infarcted brain was performed. The results were as follow;

1. No cerebral infarction was made by the uni-lateral internal carotid ligation alone.

2. Focal cerebral edema was most marked at the white matter of the embolized hemisphere.

3. The edema was also conspicuous in the deep cerebral gray matter, especially in hippocampus. Degeneration and pyknosis of the neurons were observed at the same area.

4. Transudative hemorrhage in the focal cerebral edema was usually observed in the thalamus.

5. Edematous change in the cortical gray matter was not so marked as compared with the hippo-campus and thalamus.

6. Carbon microsphere was not found in the capillaries of ipsilateral choroid plexus.

The present experimental model of cerebral infarction will be useful in elucidating the patho-logical mechanisms of the cerebral infarction.