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The Relationship between Depression-anxiety States and Irritable Bowel Syndrome Severity Kiyotaka NEMOTO 1 , Hirokazu TACHIKAWA 1 , Hideo SUZUKI 2 , Takafumi HORI 1 , Akinori YANAKA 2 , Ichinosuke HYODO 2 , Takashi ASADA 1 1Department of Psychiatry, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan 2Department of Gastroenterology and Hepatology, Division of Clinical Medicine, Faculty of Medicine, University of Tsukuba Keyword: Irritable bowel syndrome , Anxiety , Depression , Sexual dimorphism pp.327-335
Published Date 2013/4/15
DOI https://doi.org/10.11477/mf.1405102423

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 Irritable bowel syndrome (IBS) is a chronic functional gastrointestinal disorder characterized by abdominal pain associated with alterations in defecation frequency and stool consistency. In this study, we focused on the relationship between depression-anxiety states and IBS severity. We enrolled 19 men and 32 women who met ROME II criteria of diarrhea-dominant IBS. The IBS Severity Score, State-Trait anxiety Inventory-Form (STAI), and Beck Depression Inventory (BDI) were used as assessment scales. We found that IBS patients had higher STAI and BDI scores than healthy subjects. STAI and BDI significantly correlated with IBS severity. Subgroup analysis based on gender revealed that the correlation between STAI and IBS severity was only observed in males. These results suggest that males with severe IBS may need therapeutic intervention against depression and anxiety.


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電子版ISSN 1882-126X 印刷版ISSN 0488-1281 医学書院

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