心臓粘液腫における生体徴候と血中および腫瘍組織中interleukin−6活性に関する検討

Serum/Tissue Interleukin-6 Concentrations and Constitutional Abnormalities in 4 Patients with Cardiac Myxoma

　心臓粘液腫の4例を経験し，術前，術後の血液検査所見，特に炎症反応ならびに血清中interleukin−6（IL−6）活性，腫瘍組織中IL−6活性，粘液腫細胞培養上清液中のIL−6活性を検討した．術前は全例何らかの血中炎症反応が高値を示し，術後は2〜4週で正常範囲に復帰した．血清中IL−6活性は4例中3例で上昇し，腫瘍が2cm以下の1例は正常範囲であった．腫瘍組織中IL−6活性は径4.0cm以上の3症例で45,000 pg／protein gm以上と著しく高く，径2cm以下の1例でも3,500 pg／protein gmと高い値を示していた．Explant法を用いて行った粘液腫細胞の培養上清液中には培養1週目より高いIL−6活性が認められた．以上，心臓粘液腫では血清中および腫瘍組織中に高いIL−6活性が存在し，また粘液腫細胞の培養上清液中にもIL−6が遊離されることが確認された．そしてIL−6は粘液腫症例において血中炎症反応の増強に深く関与していると考えられた．

Immunological features and the production of inter-leukin-6 (IL-6) in 4 patients with cardiac myxoma were studied. The patients' age ranged from 11 years old to 57 years old ; all 4 patients were female.

Case 1, an 11-year-old female patient with myxoma located in the right ventricle, was considered to be a familial case. Her mother had myxomas in the right and left atrium, and had undergone removal of both tumors 3 years before.

Peripheral blood examination revealed various inflammatory parameters in all of these patients.