慢性うっ血性心不全に対するBunazosinの急性および慢性効果—運動負荷前後における血行動態および神経体液性因子からの検討

Acute and chronic effects of bunazosin in patients with congestive heart failure

　近年，慢性うっ血性心不全に対して血管拡張薬が臨床応用され，その有用性が認められてきている^1〜3）。

　Bunazosinはpost synaptic　α-receptorを選択的に阻害するα-blockerとして本邦で開発された。

The acute hemodynamic effect (right atrial pres-sure, mean pulmonary artery pressure, pulmonary capillary wedge pressure, cardiac index, heart rate, blood pressure) and neurohumoral response (α-ANP, plasma renin activity, aldosterone, angiotensin II ) of Bunazosin, oral α₁ blocker, was investigated in 28 patients with congestive heart failure at rest and immediately after exercise. Bunazosin reduced α-ANP, but, other neurohumoral factors did not chan-ge. Bunazosin produced significant hemodynamic improvements both at rest and after exercise.

Its chronic effect was also investigated in 11 pa-tients in 28 days after taking oral Bunazosin.

Improvement of hemodynamics at acute phase was also preserved at chronic phase without deteriora-tion of nuerohumoral factors.

It is concluded that Bunazosin may be an effective Balanced vasodilator both at acute and chronic pha-ses in patients with congestive heart failure.