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Endoscopic Diagnosis of Squamous Intraepithelial Neoplasia Akiko Takahashi 1 , Tsuneo Oyama 1 , Satoshi Shiozawa 2 , Aiko Arakawa 2 , Hiroyoshi Ota 3 1Department of Endoscopy, Saku Central Hospital Advanced Care Center, Saku, Japan 2Department of Pathology, Saku Central Hospital Advanced Care Center, Saku, Japan 3Department of Biomedical Laboratory Sciences, School of Health Sciences, Shinshu University School of Medicine, Matsumoto, Japan Keyword: 食道上皮内腫瘍 , IN , ヨード淡染 , 超拡大内視鏡 , ECS , pink color sign , metallic silver sign pp.273-282
Published Date 2022/3/25
DOI https://doi.org/10.11477/mf.1403202677

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 This study aimed to investigate the endoscopic characteristics of IN(intraepithelial neoplasia). Of the 204 cases treated by ESD(endoscopic submucosal dissection)for SCC(squamous cell carcinoma)from December 2018 to November 2021, Twenty-two cases with twenty-four IN cases were enrolled in this retrospective study. The lesions were divided into three groups as follows:Group 1:No findings by WLI and NBI, and weakly stained by iodine ; Group 2:Reddish color by WLI or Brownish color by NBI, and Weakly stained by iodine ; and Group 3:No finding by WLI and NBI, and well stained by iodine. Groups 1, 2, and 3 were 20 cases with 22 lesions(92%), 1 case with 1 lesion(4%), and 1 case with 1 lesion(4%), respectively. All the cases in groups 1 and 2 were 0-IIb and were detectable because they stained weakly by iodine. On the other hand, a case in group 3 was stained by iodine, but was found by chance because it was partially elevated.

 Group 1 accounted 92% of IN cases. All 18 cases that showed PCS(pink color sign)/MSS(metallic silver sign)negative were IN. Therefore, PCS/MSS negative is a characteristic findings of IN. On the other hand, 4 cases of PCS/MSS positive cases were also IN. However, all 4 cases showed Kumagai classification Type 2 by ECS(endocytoscopy system). Therefore, it was suggested that ECS may contribute to the differential diagnosis between IN and SCC in case of PCS/MSS positivity.


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電子版ISSN 1882-1219 印刷版ISSN 0536-2180 医学書院

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