Laugier-Hunziker-Baran症候群

・上部内視鏡検査で指摘された口腔内色素斑を契機に発見されたLaugier-Hunziker-Baran（LHB）症候群を経験した．

・LHB症候群では口唇，口腔内，指趾掌蹠皮膚に色素沈着を生じ，その分布からPeutz-Jeghers（PJ）症候群との鑑別が問題となる．

・LHB症候群に伴う色素沈着は悪性化しないが，個々の皮疹は悪性黒色腫との鑑別がむずかしい．LHB症候群と悪性黒色腫の合併例の報告もあるため，診断後も経過観察し，色素斑の変化があれば生検など積極的な精査が望まれる．

（「症例のポイント」より）

　

A case of Laugier-Hunziker-Baran syndrome

　

Ozasa, Miran1）Suzuki, Hikaru2）Ota, Arihito2）Yanaba, Koichi2） 1）Department of Dermatology, The Jikei University School of Medicine 2）Department of Dermatology, The Jikei University Katsushika Medical Center

　

A 77-year-old woman had several pigmented spots localized on the lips, tongue, and mucosa of the cheek. In addition, there were brown macules on the fingers and the left sole, and black streak on the nail. These were first noticed 10 years previously. On examination, no intestinal polyposis or adrenal dysfunction suggestive of Peutz Jeghers syndrome or Addison’s disease was noted. A biopsy of a pigmented macule from the lip revealed melanin pigmentation of the basal layer with melanophages in the upper dermis. We therefore diagnosed the patient as having Laugier-Hunziker-Baran syndrome.