第Xa因子阻害薬アピキサバンが著効したリベド様血管症

・第Xa因子阻害薬アピキサバンが著効したリベド様血管症を経験した．

・罹病期間は10年以上の長期にわたっていたが，アピキサバン開始3日目には疼痛が消失し，8週間目には潰瘍がほぼ上皮化した．

（「症例のポイント」より）

　

A case of livedoid vasculopathy successfully treated with factor Xa inhibitor apixaban

　

Yamaguchi, Yasuyuki1）Hirata, Yu2） 1）Department of Dermatology, Hokkaido University Hospital 2）Department of Dermatology, Hakodate General Central Hospital

　

An 83-year-old woman presented with recurrent painful livedoid vasculopathy on her right leg. She was relieved from the severe ischemic pain within 3 days after the initiation of oral factor Xa inhibitor apixaban. Moreover, the skin ulcer was almost epithelialized at 4 weeks. From the viewpoint of safety, the factor Xa inhibitor is superior to warfarin which is widely used for the treatment of livedoid vasculopathy. Our case suggests that the factor Xa inhibitor can be a first-line therapy for livedoid vasculopathy.