手足口病に続発した多形紅斑

・手足口病罹患1週間後に全身の多形紅斑を生じた．

・オロパタジンとプレドニゾロンの内服で紅斑は治癒した．

・ウイルス感染に続発した免疫変調により多形紅斑が生じた可能性が示唆された．

（「症例のポイント」より）

　

A case of erythema multiforme developed secondary to hand and foot mouth disease

　

Okazaki, Sari1）Osawa, Risa1）Fujioka, Ai1）Nakajima, Kimiko1）Sano, Shigetoshi1）Kitagawa, Nobuko2） 1）Department of Dermatology, Kochi Medical School, Kochi University 2）Yoshimoto Dermatology Clinic

　

A 33 years old woman, who had been recently suffered from hand and foot mouth disease, presented with bulla on the her hands and feet. About 1 week later the symptoms disappeared, exudative erythema, vesicle appeared on her trunk and limbs. Pathological findings of erythema on the abdomen showed necrotic keratinocytes, liquefaction of the basement membrane and inflammatory cell infiltrate around the small vessels at the upper dermis. Anti coxsackievirus groupA type6-NT antibody (IgG) was elevated. Skin lesions improved with oral administration of predonizolone. We considered the possibility that erythema multiforme developed secondary to hand and foot mouth disease.