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Body weight and bone/calcium metabolism. Glucose-lowering agents and fracture risk. Watanabe Reiko 1 , Inoue Daisuke 2 1Third Department of Medicine, Teikyo University Chiba Medical Center, Japan. 2Third Department of Medicine, Teikyo University Chiba Medical Center, Japan. pp.963-971
Published Date 2018/6/28
DOI https://doi.org/10.20837/4201807963
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 Diabetes is associated with increased fracture risk, involving a variety of factors. Besides poor glycemic control itself, some glucose-lowering agents are also associated with increased fracture risk. Thiazolidinediones increase fracture risk probably through inhibition of bone formation as well as increased resorption leading to decreased BMD. Sodium-glucose cotransporter(SGLT)-2 inhibitors have been reported to decrease BMD and increase fracture risk. However, the class effect of SGLT-2 inhibitors on bone metabolism remains to be established. In diabetic patients, especially in those with high fracture risk such as postmenopausal women, careful selection of glucose-lowering agents as well as appropriate and timely intervention for osteoporosis is necessary.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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