Japanese

Homeostasis and Disorder of Musculoskeletal System.Roles of the motor system in systemic metabolism and the aging-related disorders. Sasako Takayoshi 1 , Ueki Kohjiro 2 1Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo/Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan. 2Department of Diabetes and Metabolic Diseases, Graduate School of Medicine, The University of Tokyo/Diabetes Research Center, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan. pp.373-379
Published Date 2018/2/28
DOI https://doi.org/10.20837/4201803373
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 Among the tissues involved in the motor system, skeletal muscle plays an important role in systemic metabolism and is the largest organ in terms of glucose uptake. Insulin promotes anabolism of nutrients in skeletal muscle, as in other insulin-targeted organs, and maintains muscle volume, in cooperation with insulin-like growth factor-1. In humans, along with aging, insulin resistance is induced in skeletal muscle, which could lead to systemic insulin resistance, and circulating IGF-1 levels are lowered. These changes contribute to the development of sarcopenia, in which function and volume of skeletal muscle are impaired, and modulation of the insulin/IGF-1 signaling could be promising in treatment of sarcopenia.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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