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Update on drugs acting on calcium-sensing receptor. The effect of oral calcimimetics on cardiovascular events. Hamano Takayuki 1 1Department of Comprehensive Kidney Disease Research, Osaka University Graduate School of Medicine, Japan. pp.529-535
Published Date 2017/3/24
DOI https://doi.org/10.20837/4201704059
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 The Evolve Trial showed no significant benefit of cinacalcet on the primary composite outcome(death or first non-fatal myocardial infarction, hospitalization for unstable angina, heart failure, or peripheral vascular event)but significantly reduced the incidence of heart failure in an intention-to-treat(ITT)analysis. In an adjusted ITT analysis and lag-censoring analysis, the effect of cinacalcet on the primary outcome was significant. The reduced incidence of cardiovascular events in the cinacalcet arm could by predicted by a >30% reduction in FGF23 levels at week 20. In a post-hoc analysis stratified by age, cinacalcet reduced the primary outcome only in elderly patients(>65 years). In Japanese MBD-5D cohort study, cinacalcet administration was associated with significantly lower mortality in patients with baseline iPTH >500 pg/mL and lower risk of death or hospitalization due to cardiovascular events in patients with iPTH >300 pg/mL, respectively.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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