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Japanese

Osteoregulation by Physiological Stresses. Dynamics of bone resorption analyzed by intravital imaging. Kikuta Junichi 1 , Ishii Masaru 2 1Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Japan./Japan Science and Technology Agency, CREST, Japan. 2Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, Japan./Japan Science and Technology Agency, CREST, Japan. pp.1627-1633
Published Date 2013/10/28
DOI https://doi.org/10.20837/4201311079
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 By using conventional methods such as histological analysis, many osteoclasts can be observed in the site of bone destruction. However, how the bone-resorptive functions of mature osteoclasts are controlled in vivo remains unclear. To answer this question, we have originally developed an advanced imaging system for visualizing living bone tissues with intravital multiphoton microscopy. Using this system, we succeeded in visualizing bone resorption of mature osteoclasts in living bone. Here we show the latest data and also discuss the further application of intravital bone imaging. This approach would be quite useful for evaluating novel anti-bone-resorptive drugs in vivo.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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