Japanese

Osteoimmunology~Beyond the Boundaries~. Analysis of bone tissues by intravital imaging. Mizuno Hiroki 1 , Yamashita Erika 2 , Ishii Masaru 3 1Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences,Osaka University, Japan. /AMED-CREST, AMED, Japan. 2Department of Immunology and Cell Biology, Graduate School of Frontier BioscOsaka University, Japan/AMED-CREST, AMED, Japan. 3Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences,Osaka University, Japan/AMED-CREST, AMED, Japan. pp.729-734
Published Date 2016/4/28
DOI https://doi.org/10.20837/4201605729
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 In recent years,“the fluorescent imaging techniques”has made rapid advances, it has become possible to observe the dynamics of living cells in individuals or tissues. It has been considered that it is extremely difficult to observe the living bone marrow directly because bone marrow is surrounded by a hard calcareous. But now, we established a method for observing the cells constituting the bone marrow of living mice in real time by the use of the intravital two-photon imaging system.  In this article, we show the latest data and the reports about the hematopoietic stem cells and the leukemia cells by using the intravital imaging techniques, and also discuss its further application.



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電子版ISSN 印刷版ISSN 0917-5857 医薬ジャーナル社

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