中年の延髄に発生したdiffuse midline glioma，H3 K27-alteredの1例

An adult case of H3 K27-altered diffuse midline glioma located in the medulla oblongata

diffuse midline glioma，H3 K27-altered（DMG-A）は，2021年脳腫瘍WHO分類でgrade 4として採用されている主に小児の脳幹（特に橋）に発生する悪性神経膠腫である。今回我々は，50歳代女性の延髄発生というDMG-Aとしては疫学・部位的に非典型な症例を経験したので，文献的考察とともに報告する。

A 50-year-old woman presented with worsening dizziness for one year. Head CT and MRI revealed a mass with a small cyst located in the medulla oblongata. The mass showed mild hyperintensity on T2-weighted images without diffusion restriction, with nodular enhancement and little peritumoral edema. When a medullary tumor is found, H3 K27-altered diffuse midline glioma should be included in the differential, even in middle-aged patients.