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骨転移は乳癌,前立腺癌患者の75%,肺癌,甲状腺癌の50%にみられる非常に頻度の高い疾患である1)。その中でも脊椎転移は疼痛やしびれなどの症状の原因となり,圧迫骨折や脊髄圧迫症候群をきたすこともある。骨転移に対する緩和照射の疼痛緩和率は59~73%であり,しびれの緩和率は53~61%である2-5)。また脊髄圧迫をきたす頻度を1.6~3.0%に抑えられたという報告もある3)4)。脊椎転移に対する緩和照射は非常に重要な治療である。
Palliative radiation therapy for symptomatic vertebral metastases is effective, but radiation-induced acute toxicities may impair the quality of life. Therefore, efforts to reduce the toxicities as low as possible is required. We conducted a retrospective study to determine the advantage of IG-IMRT over 3DCRT. According to CTCAE ver. 4, nausea G1-2 was shown at 12.4%, vomit G1:2.0%, diarrhea:G1-2:3.0%, dysphagia G1-2:6.4%, and dry mouth G1-2:1.0%. This study demonstrated acute toxicities induced by IG-IMRT were lower than those by 3DCRT previously reported, although prospective study is required.
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