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Japanese

Diuretic Action of Digitalis Tsuneyoshi Tanabe 1 1Department of Pharmacology, Hokkaido University, School of Medicine pp.124-129
Published Date 1960/6/15
DOI https://doi.org/10.11477/mf.2425906131
  • Abstract
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 The mechanism of the diuretic action of cardiac glycosides was discussed in this review article on the basis of recent literatures and data obtained by the author and his collaborators. Ouabain injected into the left renal artery produced a continuing marked increase in urinary excretion as well as sodium excretion from the left kidney while urinary output was unchanged or decreased in the right kidney. It was proved by direct method with bubble flow meter and by clearance test that blood flow decreased only in the left kidney in which ouabain had been injected. It was noted that the increase in potassium excretion was not closely related to diuresis produced by ouabain, since it was not so marked or negative in dogs as in rats which showed a constant increase in potassium excretion by ouabain.

 The author concluded that ouabain inhibits the reabsorption of sodium in renal tubule and produces diuresis with no direct connection with the action on the heart.


Copyright © 1960, THE ICHIRO KANEHARA FOUNDATION. All rights reserved.

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電子版ISSN 1883-5503 印刷版ISSN 0370-9531 金原一郎記念医学医療振興財団

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