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Plasma Neopterin as an Adjunct to C-Reactive Protein in Assessment of Infection pp.348-349
Published Date 1992/4/1
DOI https://doi.org/10.11477/mf.1543901008
  • Abstract

C-reactive protein (CRP) concentrations are increased in plasma in people with inflammatory conditions and bacterial infections. Plasma neopterin concentrations are increased in people with bacterial septicemias, viral infections, and graft vs host disease. Plasma concentrations of CRP and neopterin were measured daily in 21 bone-marrow transplant (BMT) patients, 64 patients in intensive-care units (ICU), and 12 patients with squamous cell carcinoma of the head and neck (HN). In the BMT patients, plasma neopterin measurements in addition to CRP measurements allowed infectious episodes to be distinguished from graft vs host disease.In the ICUpatients, increased concentrations of CRP were not specific for infection andthe additional plasma neopterin measurements did not improve thisspecificity. In all three patients groups, the derivation of a neopterin/CRPratio was of no clinical use. These three groups of patients showed patternsof CRP and neopterin concentrations characteristic of their underlyingdiseases, the BMT patients with the immunological activation of graft vshost disease showed predominantly increased concentrations of plasmaneopterin, ICU patients with infectious and inflammatory conditions hadincreased concentrations of both CRP and neopterin in plasma, and the HNgroup with localized inflammation showed increased plasma concentrationsof CRP without increases in neopterin.


Copyright © 1992, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1375 印刷版ISSN 0301-2611 医学書院

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