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Effects of Storage Time and Temperature on Measurement of Small Concentrations of Albumin in Urine pp.482-483
Published Date 1991/5/1
DOI https://doi.org/10.11477/mf.1543900614
  • Abstract

 An increased albumin excretion rate (AER) measured overnight or during resting reflects an incipient stage of diabetic nephropathy in the absence of urinary tract infection. Accurate measurements of urinary albumin excretion are important clinically, because of speculation that early diabetic renal damage may be reversible if albumin spillage can be detected while still slight (“microalbuminuria”). The range of AER within which reversibility with medications is considered possible currently is believed to be between 30 and 200μg/mim. Studies in progress at our Center suggest that spillage in the 10 to 30μg/min range in overnight urine collections may be reversible just byimproved glucose control. Similarly, exercise-induced microalbuminuria, which may be present in subjects who still have a normalovernight AER of <10μg/min, may be reversible with improvedglucose control.

 It is imperative to have accurate determinations of small amountsof albumin spillage. Radioimmunoassay is capable of yielding accurate laboratory determinations. However, more information is neededabout the effect of specimen storage conditions on the accuracy ofresults. A recent study showed that storage of urine specimens for twoor six months at-20℃ resulted in falsely low albumin concentrationsmeasured nephelometrically.


Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1375 印刷版ISSN 0301-2611 医学書院

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