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New paradigm of diagnosis and treatment of rheumatoid arthritis Yoshiya Tanaka 1 1The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Keyword: 関節リウマチ , 診断 , 治療 pp.1142-1149
Published Date 2011/10/30
DOI https://doi.org/10.11477/mf.1542102795
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Rheumatoid arthritis (RA) is a systemic, chronic and destructive inflammatory disease that causes severe disability and mortality. Since joint destruction occurs from the early stage of the disease, its diagnosis and treatment have to be carried out early. 2010 RA classification criteria redefine the current paradigm of RA by focusing on features at earlier stages of the disease that are associated with persistent and/or erosive disease. The combinational use of methotrexate and biologics targeting TNF and IL-6 has revolutionized the treatment of RA, producing significant improvement in clinical and structural outcome. It has enabled an upcoming endpoint, clinical and structural remission, for the treatment.


Copyright © 2011, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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