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Anti-inflammatory cytokines IL-10 and IL-35 Izuru Mizoguchi 1 , Noriko Morishima 1 , Masae Okumura 1 , Yukino Chiba 1 , Takayuki Yoshimoto 1 1Intractable Disease Research Center, Tokyo Medical University Keyword: IL-10 , Tr1細胞 , IL-35 pp.607-613
Published Date 2010/6/15
DOI https://doi.org/10.11477/mf.1542102311
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Interleukin(IL)-10 is an anti-inflammatory cytokine, which plays critical roles in induction and maintenance tolerance and control of excessive immune reaction. IL-10 limits the immune response to pathogens in certain infection and thereby prevents damage to the host. IL-10 is also essential for homeostasis of the immune system in the gastrointestinal tract by controlling the aberrant immune responeses to commensal bacteria. IL-10 is produced by many types of immune cells including naturally occurring Foxp3+ regulatory T(Treg)cells, inducible Treg(iTreg), IL-10-secreting type 1 Treg(Tr1)cells, Th1 cells, Th2 cells and Th17 cells. IL-35 is the newest cytokine, which is produced by Treg cells and plays a role in exertion of immune suppressive activity like IL-10 and transforming growth factor(TGF)-β


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電子版ISSN 1882-1367 印刷版ISSN 0485-1420 医学書院

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