Germinoma症例の化学療法後に発生したB型急性肝炎の1症例

Acute Hepatitis B Virus after Chemotherapy for a Case with Germinoma

I．はじめに

　胚細胞腫をはじめとして化学療法が行われる脳腫瘍は多い^{2,3,6,8,10,11,12,16）}．しかしながら，化学療法による骨髄抑制のためB型肝炎ウイルス（HBV）をはじめとする不顕性感染症が活性化することがある^4,5,13）．今回われわれはB型肝炎HBs抗原陽性患者に行った化学療法によって，HBが活性化して急性肝炎へ移行した症例を経験したので，文献的考察を加えて報告する．

A 28-year old man with HCG-producing germinoma had undergone chemotherapy and radiotherapy. On admission for the fifth session of maintenance chemotherapy, he was found to be positive for hepatitis B (HB) s antigen, but negative for HBs antibody. HBs antigen had been negative during previous admissions. Since liver function was normal, the patient underwent chemotherapy. During myelosuppression after che- motherapy, liver dysfunction developed and acute HB was diagnosed. He fortunately showed seroconver- sion 2 months after onset. Serum immunological examinations are required for patients receiving che- motherapy.