A Case of Radiation-induced Glioblastoma 29 Years after Treatments for Germinoma Ayaka MATSUO 1 , Ichiro KAWAHARA 1 , Tomoya MORITSUKA 1 , Kazuya HONDA 1 , Takehiro ITO 1 , Wataru HARAGUCHI 1 , Takeshi HIU 1 , Tomonori ONO 1 , Ryujiro USHIJIMA 1 , Keisuke TSUTSUMI 1 1Department of Neurosurgery, Nagasaki Hospital Organization Nagasaki Medical Center Keyword: germinoma , glioblastoma , long-term survivor , radiation-induced pp.793-799
Published Date 2020/9/10
DOI https://doi.org/10.11477/mf.1436204275
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 Intracranial germinomas are considered one of the most radiosensitive tumors and are curable by radiotherapy alone. Although patients can expect long-term survival, the adverse effects of radiotherapy and late sequelae in survivors are a major concern. Radiation-induced secondary neoplasms are one of those sequelae and are a serious concern because they are often connected directly with life prognosis.

 We describe a case of radiation-induced glioblastoma after radiotherapy for germinoma. An 11-year-old boy with basal ganglia germinoma was successfully treated with postoperative cranial irradiation. At the age of 40 years, he was admitted to our hospital for aphasia and memory disturbance. CT and MRI revealed a tumor in the left parietal lobe with dissemination. The tumor of the parietal lobe was removed surgically, and pathohistologically, it was diagnosed as glioblastoma.

 Long-term survivors who receive radiotherapy for germinomas in childhood are at risk for late complications, including radiation-induced neoplasms. Therefore, careful follow-up neurological examinations are recommended in these patients, even 20-30 years after radiotherapy.

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