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Intracranial Primitive Neuroectodermal Tumor in an Infant : a case report Kimio YOSHIZATO 1 , Susumu YOSHIOKA 1 , Tomoharu TAMAI 2 , Kouichi TSUJI 3 , Shunji NISHIO 4 1Departments of Neurosurgery, Oita Prefectural Hospital 2Departments of Pediatrics, Oita Prefectural Hospital 3Departments of Pathology, Oita Prefectural Hospital 4Department of Neurosurgery, Neurological Institute, Faculty of Medicine, Kyushu University Keyword: PNET , clinical feature , MIC2 , infancy pp.243-248
Published Date 1999/3/10
DOI https://doi.org/10.11477/mf.1436901691
  • Abstract
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A 2-month-old girl with a supratentorial primitive neuroectodermal tumor (PNET), which extended intothe skull, is herein presented. The patient underwent total removal of the tumor and also received a courseof postoperative chemotherapy. After a follow-up period of 12 months, the infant is alive without recur-rence. Histologically, the tumor was composed of poorly differentiated neuroectodermal cells, and theseneoplastic cells showed a mild immunohistochemical reaction for GFAP and synaptophysin, and a moder-ate reactivity for neuron specific enolase and vimentin. In addition, a moderate level of immunoreactivityfor HBA71 antigen (p30/32MIC2), which is the product of the MIC2 gene and is found in peripheral PNETsbut not in central PNETs, was noted in many neoplastic cells. Although this tumor was located intracra-nially, it may be classified as a peripheral PNET.


Copyright © 1999, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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