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Clinical Significance of Thrombocytopenia Associated with Hemorrhagic Cerebrovascular Diseases Kouji KOIDE 1 , Shinya MANAKA 1 , Jun SASHIDA 1 , Kiyoshi TAKAGI 1 , Takayuki KITAMURA 1 , Makoto HIRAKAWA 1 , Satoshi NOMAGUCHI 1 1Department of Neurosurgery, Ichihara Hospital, University of Teikyo School of Medicine Keyword: Thrombocytopenia , Subarachnoid hemorrhage , Intracerebral hemorrhage , H2—blocker , Phenytoin pp.729-734
Published Date 1991/8/10
DOI https://doi.org/10.11477/mf.1436900301
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Abstract

We investigated the clinical significance of throm-bocytopenia (platelet counts less than 10 × 104/mm3) associated with hemorrhagic cerehrovascular diseases. This study was conducted in 96 patients suffering from hemorrhagic cerebrovascular diseases. We divided the clinical course into 3 stages : acute (from the 1st to 7th day) , subacute (8th - 21st day) and chronic (after the 22nd clay). The average age of the patients with throm-bocytopenia (TCP) was 60.6 years old. TCP was More frequent in men (81.3%) than in women (18.7%) . TCP developed in 18.6% (8/43) of patients with subarach-noicl hemorrhage (SAH) and in 15.1% (8/53) of those with intracerebral hemorrhage (ICH) . Among the pa-tients with SAH, four were in the acute stage, three in the subacute stage and two in the chronic stage. TCP due to SAH was more likely to develop in the acute and/or subacute stage. TCP due to SAH showed two peak appearances : the first was within 24 hours (n 3), and the second was around 10 clays after onset (n= 3) . The cause of TCP in its late peak appearance was presumed to be the consumption of platelets clue to microembolism induced by vasospasm and/or hemo-dilution therapy. Among patients with ICH, five cases were in the acute stage, three in the subacute stage and two in the chronic stage. TCP clue to ICH was more likely to develop in the acute stage. Fifty percent (4/8)of the patients with ICH had TCP on admission. This data suggested that TCP was possibly a cause or an in-ducer for ICH. The causes of TCP due to SAH were DIC (n = 2) , liver dysfunction (n = 2) , DIC and liver dysfunction (n = 2) and drug induced (n =- 2), whereas those of TCP due to ICH were liver dysfunction (n = 4), DIC and liver dysfunction (n=2), renal dysfunction (n = 1) , and drug-induced (n = 2) . In the ICH group, five patients (63%) had liver dysfunction, which was assumed to be the most important risk factor for TCP. Drug-induced TCP was observed in a total of five cases, including one recurrent case. In one of the five cases, myelosuppression was observed, and in four cases antiplatelet antibodies were observed. Platelet counts in patients with clrug-inclucd TCP were less than in those effected by other causes.


Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1251 印刷版ISSN 0301-2603 医学書院

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