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A Case of Adult Pilocytic Astrocytoma in the Right Temporal Lobe Shigeyoshi NAKAJIMA 1 , Makoto MIZUNO 1 , Takeshi SAMPEI 1 , Nobuyuki YASUI 1 , Eriko YOKOYAMA 2 , Kazuo UEMURA 3 , Hitoshi FUKASAWA 4 1Department of Surgical Neurology, Research Institute for Brain and Blood Vessels-Akita 2Department of Neurology, Research Institute for Brain and Blood Vessels-Akita 3Department of Radiology and Nuclear Medicine, Research Institute for Brain and Blood Vessels-Akita 4Department of Pathology, Research Institute for Brain and Blood Vessels-Akita Keyword: Pilocytic astrocytoma , Cerebral hemisphere , Psychomotor seizure , MRI , Positron Emission Tomography(PET) pp.689-694
Published Date 1991/7/10
DOI https://doi.org/10.11477/mf.1436900296
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Abstract

A case of adult pilocytic astrocytoma in the right temporal lobe is reported here.

The patient was a twenty-four year old man, who came to the neurological division of our hospital on October 6, 1987 because of repeated consciousness-loss attacks accompanied with uncinate fit. He had no neu-rological deficits. However, an EEG revealed spike-and-wave complexes in the right temporal region, and a CT scan showed a small cystic lesion in the right temporal lobe. A diagnosis of psychomotor seizure was made, and the administration of anticonvulsants was started.The incidence of attack then decreased, but after approximately two years of drug therapy the attacks increased again. A CT scan was again performed, and revealed that the lesion in the right temporal lobe was enlarging. Also a noticeable enhanced lesion, identified as a mural nodule was found in the post-contrast en-hancement study. A brain tumor was then suspected, and he was admitted to the neurosurgical division on October 11, 1989.

He had no neurological deficits on admission. An MRI showed a low intensity lesion in the T1 weighted image, and a high intensity lesion in the T2 weighted image. A cystic lesion with a marked enhanced mural nodule was also found in the base of the right temporal lobe, according to the Gd enhancement study. Perifocal edema was not recognized. Cerebral angiography showed no positive findings. Positron emission tomography (PET) , using H215O, revealed low perfu-sion at or around the lesion, and PET using [11C] -methionine revealed an accumulation of methionine at the lesion.

A diagnosis of low-grade glioma was made, and a right temporal craniotomy, for the purpose of totally re-moving the tumor was performed on October 26, 1989. The tumor was found in the subcortical region at the base of the right temporal lobe, just above the pyramid- al bone. A yellowish discoloration of the cortical sur-face was recognized. The tumor had a small cyst con-taining yellowish fluid, and a mural nodule of 1cm in diameter. The mural nodule was soft and grayish white. We completely removed the mural nodule and the cyst wall.

A histopathological investigation revealed that the tumor was pilocytic astrocytoma, and showed a few Rosenthal fibers and granular bodies.

Pilocytic astrocytoma is often seen in either the optic nerve or the cerebellum in children, but rarely seen in the adult cerebral hemisphere. According to the pub-lished literature, the incidence of lobar pilocytic astrocytoma is less than 1% of all brain tumors, and only 1% - 2% of all supratentorial gliomas. Some au-thors, however, have said that they are more frequent in children than in adults. Also, according to the litera-ture, the characteristics of lobar pilocytic astrocytoma are as follows : 1) The tumors are often seen in the temporal lobe of children or young adults, 2) cystic tumors are frequently found with a mural nodule, 3) the most frequent initial symptoms are epilepsy, or signs of increased intracranial pressure, 4) the prognosis is generally good, but only if the tumor is not deep seat ed, is not solid, and if total removal is possible. Radio-therapy and chemotherapy are both considered un-necessary as follow-up therapies. Our case is considered a typical case of lobar pilocytic astrocytoma of adult.


Copyright © 1991, Igaku-Shoin Ltd. All rights reserved.

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