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Neurological Surgery No Shinkei Geka Volume 51, Issue 5 （September 2023）

Neurological Surgery 脳神経外科 51巻5号（2023年9月発行）

Japanese English

特集臨床脳神経外科医にとってのWHO脳腫瘍分類第5版

Ⅳ 小児脳腫瘍

限局性星細胞系膠腫 Circumscribed Astrocytic Gliomas 林弘明 ¹ , 岩下広道 ² , 立石健祐 ^3,4 Hiroaki HAYASHI ¹ , Hiromichi IWASHITA ² , Kensuke TATEISHI ^3,4 ¹横浜市立大学大学院医学研究科発生成育小児医療学 ²横浜市立大学大学院医学研究科病態病理学 ³横浜市立大学大学院医学研究科脳神経外科学 ⁴横浜市立大学大学院生命医科学研究科創薬再生科学研究室 ¹Department of Pediatrics, Yokohama City University Graduate School of Medicine ²Department of Pathology, Yokohama City University Graduate School of Medicine ³Department of Neurosurgery, Yokohama City University Graduate School of Medicine ⁴Laboratory of Biopharmaceutical and Regenerative Sciences, Yokohama City University Graduate School of Medical Life Science キーワード：脳腫瘍 , 限局性星細胞系膠腫 , MAPK経路 , brain tumor , circumscribed astrocytic gliomas , MAPK pathway Keyword: 脳腫瘍 , 限局性星細胞系膠腫 , MAPK経路 , brain tumor , circumscribed astrocytic gliomas , MAPK pathway pp.884-891

発行日 2023年9月10日 Published Date 2023/9/10

DOI https://doi.org/10.11477/mf.1436204830

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Point

・WHO脳腫瘍分類第5版では，新たに限局性星細胞系膠腫が加わった．

・限局性星細胞系膠腫には，毛様細胞性星細胞腫，多形黄色星細胞腫をはじめとする6つの腫瘍型が含まれる．

・限局性星細胞系膠腫の多くでMAPK経路の遺伝子異常が認められる．

　In the fifth edition central nervous system tumours volume of the WHO Classification of Tumours series, gliomas, glioneuronal tumors, and neuronal tumors are divided into six groups. The term“circumscribed”is used to refer to a relatively contained growth pattern, as compared to other inherently“diffuse”tumors. Circumscribed astrocytic gliomas include six types: pilocytic astrocytoma, high-grade astrocytoma with piloid features, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, chordoid glioma, and astroblastoma, MN1-altered. The vast majority of circumscribed astrocytic gliomas harbor genetic alterations in the mitogen-activated protein kinase pathway. Here, we review the circumscribed astrocytic gliomas, including etiology, clinical and imaging features, pathology and molecular genetics, treatment, and prognosis. This study will lead to better understanding of these newly classified tumors.