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Neurological Surgery No Shinkei Geka Volume 47, Issue 11 （November 2019）

Neurological Surgery 脳神経外科 47巻11号（2019年11月発行）

Japanese English

症例

c-Myc転座とBcl-2蛋白発現を有するhigh grade B-cell lymphomaの急速進行例 A Case of Rapidly Progressing High-grade B-cell Lymphoma with c-Myc Translocation and Bcl-2 Protein Expression 森永裕介 ¹ , 新居浩平 ¹ , 坂本王哉 ¹ , 井上律郎 ¹ , 光武尚史 ¹ , 花田迅貫 ¹ , 堤正則 ¹ Yusuke MORINAGA ¹ , Kouhei NII ¹ , Kimiya SAKAMOTO ¹ , Ritsurou INOUE ¹ , Takafumi MITSUTAKE ¹ , Hayatsura HANADA ¹ , Masanori TSUTSUMI ¹ ¹福岡大学筑紫病院脳神経外科 ¹Department of Neurosurgery, Fukuoka University Chikushi Hospital キーワード： high grade B cell lymphoma , primary central nervous system lymphoma , c-Myc , Bcl-2 , rapid progress , poor prognosis factor Keyword: high grade B cell lymphoma , primary central nervous system lymphoma , c-Myc , Bcl-2 , rapid progress , poor prognosis factor pp.1179-1184

発行日 2019年11月10日 Published Date 2019/11/10

DOI https://doi.org/10.11477/mf.1436204096

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Abstract 文献概要
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参考文献 Reference

Ⅰ．はじめに

　今回われわれは痙攣発症から第45病日で死亡に至ったc-Myc転座とB-cell lymphoma（Bcl)-2蛋白発現を有するprimary central nervous system lymphoma（high grade B-cell lymphoma［HGBL］of PCNSL）の急速進行例を経験したため，文献的考察を加えて報告する．

　We report a case of rapidly progressing primary high-grade B-cell lymphoma of the central nervous system with c-Myc translocation and Bcl-2 protein expression that resulted in the patient's death 45 days after the onset of convulsions. Further, we provide a literature review.

　CASE:A 74-year-old man was admitted to our hospital for convulsions. Magnetic resonance imaging on admission showed tumorous lesions at the left temporoparietal junction. An open biopsy was performed promptly. The patient was diagnosed with primary high-grade B-cell lymphoma of the central nervous system with c-Myc translocation and Bcl-2 protein expression（＜50%). The tumor showed rapid progression postoperatively. The patient did not respond to steroids and died 45 days after the onset of convulsions.

　CONCLUSION:The c-Myc translocation, showing a strong c-Myc protein positivity, and co-expression of the Bcl-2 protein were poor prognostic factors for the tumor.