両側性網膜芽細胞腫の治療15年後に発生した頭蓋内線維肉腫—Cisplatin, VP−16併用化学療法の有効性

Intracranial Fibrosarcoma Fifteen Years after Radiotherapy for Bilateral Retinoblastomas: Effect of combined chemotherapy with cisplatin and VP-16

I．はじめに

　網膜芽細胞腫は二次性腫瘍の多発する疾患として知られている．特に両側性網膜芽細胞腫ではその頻度が高く，その原因として遺伝的素因が関係していると言われている．

　今回われわれは両側性網膜芽細胞腫の治療後約15年経て発生した左眼瞼部より頭蓋内に進展した巨大線維肉腫に対し，手術後CisplatinとVP−16併用化学療法にて完全寛解した症例を経験したので報告する．

We report intracranial fibrosarcoma which developed after radiotherapy for bilateral retinoblastomas. A 16-year-old boy was admitted with swelling of his left eyelid as his chief complaint on September 10, 1987. He had a past history of bilateral retinoblastomas at one year of age, which was treated by bilateral ophthalmec-tomy and postoperative radiotherapy ; 50 Gy to right eye and 60 Gy to left eye. Until fifteen years old, he had no trouble except blindness. On admission, a dumb-bell type huge tumor with the destruction of the orbital roof was demonstrated on CT scan and MRI.