Monoclonal antibodies inhibiting synaptic functions. Yoichiro KURODA 1 , Kazuo KOBAYASHI 1 , Yoshiko OOGUCHI 1 1Department of Neurochemistry, Tokyo Metropolitan Institute for Neurosciences pp.224-232
Published Date 1987/4/10
DOI https://doi.org/10.11477/mf.1431905878
  • Abstract
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Some monoclonal antibodies directed to an antigen molecule can block or change a specific function of the antigen. Such antibodies as specific neurotoxins, are useful tools to explore unknown functional molecules in the nervous system. We have developed a "two-step screening method" to obtain monoclonal antibodies whose antigens are located on the cell surface which are involved in various synaptic functions. From a library of monoclonal antibodies against cell surface antigens of PC-12 cells, we screened out a monoclonal antibody which inhibited synaptic transmission in rat superior cervical ganglion.

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