Special Lecture・III NEUROCHEMICAL CORRELATES OF BEHAVIOR

　In previous studies from our laboratories, it was demonstrated that a quantitative relationship existed between the dose of intramusclarly administered 5-hydroxytryptophan (5-HTP), the precursor of serotonin (5-HT), and the behavioral effect it produced, implying that the behavioral impairment correlated with the increase in brain serotonin. The behavioral changes were quantitatively measured employing operant (learned behavior) techniques. Further attempts to correlate disrupted behavior (‘T') with the brain level of 5-HT were assessed by employing another means of increasing this transmitter.