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Apoptosis in muscular dystrophy Ryoichi MATSUDA 1 1Department of Life Sciences, The University of Tokyo at Komaba Keyword: デュシェンヌ型筋ジストロフィー , DMD , mdxマウス , アポトーシス pp.265-270
Published Date 2000/4/10
DOI https://doi.org/10.11477/mf.1431901145
  • Abstract
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In 1995, we had developed a vital staining method to visualize degenerated muscle fibers in mdx mouse. Combining this vital staining, TUNEL technique and gel electrophoresis of genomic DNA in the degenerating muscle, we had shown that degenerating muscle fibers undergo apoptosis in mdx mouse. Since then, many papers showing apoptosis in dystrophic muscle in animal models and human patients appeared. Now, apoptosis has been recognized as one of key steps in pathogenesis of muscular dystrophy. Understandings on apoptotic processes in dystrophic muscle may provide clues for new development of therapeutic strategies.


Copyright © 2000, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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