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Influenza-associated encephalopathy Tsuneo Morishima 1 1Department of Pediatrics, Okayama University, Graduate School of Medicine and Dentistry Keyword: インフルエンザ , 急性脳症 , サイトカイン , 血管内皮細胞 , ゲノムプロジェクト pp.837-842
Published Date 2004/12/10
DOI https://doi.org/10.11477/mf.1431100242
  • Abstract
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 Recently, the number of reports of encephalitis/encephalopathy associated with influenza has increased in Japan. The abrupt onset of seizure and coma within a few days after development of high-grade fever is a prominent indicator of CNS involvement during influenza infection. Case definition of the disease is based on altered or loss of consciousness associated with influenza. Most of them are younger than 6 year old, and the mortality was 30%. Elevation of pro-inflammatory cytokines(TNF-a and IL-6)and the damage of vascular endothelial cells have been demonstrated. Recent studies have shown that apoptosis rapidly occur in nerve tissues and in liver. Influenza virus was undetectable in the brain tissues. The genome project using DNA tips and SNPs has been conducted to find genetic variations among children with influenza-associated encephalopathy.


Copyright © 2004, Igaku-Shoin Ltd. All rights reserved.

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電子版ISSN 1882-1243 印刷版ISSN 0001-8724 医学書院

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